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High concentrations of ERU (30-100 mol/L) induce apoptosis by reducing the levels of phosphorylated ERK1/2 and upregulating the expression of caspase-3 and caspase-7, thereby inhibiting cancer cell proliferation

Low angiotensinogen levels in the brain lead to anxiety-like behaviors and depression-like behaviors, while intracerebroventricular administration of Ang-(17), selective serotonin reuptake inhibitor fluoxetine, enalapril (ACEI) attenuated behavioral changes in transgenic hypertensive rats, as shown by spending a lower percentage of time in the open arms of EPM and decreasing immobility time in FST (25, 38)

PMID: 10611165, DOI: 10.1016/s0016-5085(00)70425-2